Approved research

Polygenic prediction of imaging for functional characterization of psychiatric GWAS

Lay summary

Mental disorders have substantial morbidity and mortality, contributing to devastating emotional, social and financial tolls on sufferers and their families. We will study the genetic risk architecture of mental disorders, with a focus on the expressed portion of the human genome and imaging of the brain. We will use computational models, based on common genetic variants and brain gene expression, to predict the genetic component of brain imaging of hundreds of thousands of people to better understand the mechanisms that give rise to these disorders.