Impact of treatment on cardiovascular outcomes amongst breast cancer participants in the UK Biobank

Federation University

Lay summary

1a: Breast cancer is the most common malignant tumour in women leading to the major cause of death and poor quality of life. Although advanced cancer therapy provides effective results but some serious side effects should be taken into consideration especially adverse cardiac outcomes. There are limited population-based data on cardiovascular outcomes in breast cancer patients having different types of treatment. The proper understanding of these associations will provide a benefit for managing breast cancer in routine clinical practice.

1b: UK Biobank aims to improve the prevention, diagnosis and treatment of a wide range of serious diseases, including cancer. This study aligns very closely with the purpose of UK Biobank and addresses significant issues in the public health. We will conduct a population-based retrospective cohort study to determine the incidence of adverse cardiac events and its association with cancer treatment regimen in women with breast cancer in UK Biobank. This study is unique in taking into account related risk to evaluate long-term cardiac risks. This will provide a benefit for managing breast cancer with considering the whole spectrum of risks versus benefits in clinical practice Findings from this study:

1.) To determine the incidence of adverse cardiac events and its association with cancer treatment regimen in women with early-stage breast cancer in general practice in UK Biobank 2.) To examine associated potential risk factors and risk of major cardiovascular events and to provide understanding of cardiovascular outcomes in long- term follow up in breast cancer survivor 3.) To identify breast cancer treatment and cancer clinical outcomes such as the disease treatment pattern, incidence, recurrence, breast cancer survival, overall survival and death rate in clinical practice

1c: Using all available large population-based cohort comprising breast cancer patients diagnosed before age 70 years. An association between adverse cardiac events and its association with cancer treatment regimen will investigated in the cohort and general population using advanced statistical techniques.

1d: All clinical data and cancer outcomes will be requested for the full cohort. Linkages to death and cancer registry data will require studying data of cancer treatment, cardiovascular risk, death and survival.