Gene mapping and genetic correlation across complex traits
Approved Research ID: 25331
Approval date: April 18th 2017
Lay summaryPreviously we have used the GWAS approach to map genes for a range of complex diseases. We have shown that loci overlap between a wide variety of complex traits. We will extract information on the full range of traits measured by UK Biobank and combine this with GWAS data we have in hand for a wide range of complex traits (including various cancers, eye disease, psychiatric traits). We will use the combined data to map novel loci for each trait as well as to estimate the overlap between traits. Our work will provide insights into the relationship between a wide range of complex traits. In the future this may help us improve our understanding of the molecular aetiology of complex trait risk. We will extract information on a wide range of traits and diseases and use UK Biobank array data, together with our own data, to test if there is a significant genetic overlap between traits. We will conduct analysis attempting to identify the specific genes underpinning each trait. Full cohort.
- Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
- Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration.
- Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology
- Genetic heterogeneity in self-reported depressive symptoms identified through genetic analyses of the PHQ-9
- Association between coffee consumption and overall risk of being diagnosed with or dying from cancer among >300 000 UK Biobank participants in a large-scale Mendelian randomization study.
- Effect of increased body mass index on risk of diagnosis or death from cancer
- Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health
- Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium
- Association Between Population Density and Genetic Risk for Schizophrenia
- Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation.
- Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies
- Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
- Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study
- Height and overall cancer risk and mortality: evidence from a Mendelian randomisation study on 310,000 UK Biobank participants
- Polygenic risk scores allow risk stratification for keratinocyte cancer in organ transplant recipients
- Genetic Aetiology of Self-Harm Ideation and Behaviour
- Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration
- Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
- Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
- Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging