Approved Research

A life course approach investigating genetic and lifestyle associations contributing to cardiovascular disease risk

Lay summary

We will use multiple UK Biobank resources to better understand the relationship between both genetic and environmental factors with cardiovascular diseases including congenital heart disease. Over the course of the project we aim to discover novel associations influencing disease risk, the reasons why some other diseases occur together with cardiovascular disease, and discover factors that influence the severity of disease over time. This could ultimately impact future healthcare as it may enable earlier diagnosis and treatment in families affected by these conditions, improving the development of personalised care pathways.